As with actinic keratoses, it is widely accepted that this lesion is due to excessive sun exposure. The term actinic keratosis (AK) was coined in 1958 and means literally thickened scaly growth (keratosis) caused by sunlight (actinic). [7] Several benign and malignant skin disorders can mimic AK, including seborrheic keratosis, discoid lupus erythematosus, atopic dermatitis, and squamous cell carcinoma (SCC). This paper. Differential diagnosis of exfoliative cheilitis. Chronic actinic cheilitis with leukoplakia actinic cheilitis 21. Medicines and therapies. [ 3 ] Cutaneous horn: hypertrophic conical-shaped protuberance growing from the surface of the skin; underlying AKs in 19% to 37%. (Picascia and Robinson give a comprehensive review of the etiology, clinical spectrum, histology, and treatment options for actinic cheilitis. They can potentially progress into squamous cell carcinoma (SCC). Typically, they occur in middle-aged or older men with light-coloured skin and a history of chronic sun exposure. 2 Cheilitis granulomatosa: A rare condition manifesting as an episodic, non-tender enlargement of one or both the lips. It is essential to distinguish between cheilitis (benign inflammation), premalignant actinic cheilitis, and squamous cell carcinoma. In this article we review the etiology, clinical spectrum, histology, differential diagnosis, and treatment of actinic cheilitis. There is an atopic tendency in 10-20 per cent of patients with cheilitis. Differential diagnosis. Actinic cheilitis is the counterpart of actinic keratosis of the skin and can also develop into squamous cell carcinoma. DIFFERENTIAL DIAGNOSIS OF CHEILITIS – HOW TO CLASSIFY CHEILITIS? Share. Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. What is the dermoscopic differential diagnosis of actinic keratosis? Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. Differential Diagnosis of Actinic Keratosis The relatively nonspecific clinical features of AK can make differential diagnosis challenging. Actinic cheilitis (also known as "farmer's lip" or "sailor's lip"') represents confluent actinic keratoses on the lips, most often the lower lip. Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Create a free account to download. Atopy, actinic damage, exfoliative cheilitis, cheilitis granulomatosa or glandularis, contact dermatitis, photosensitivity reactions and neoplasia should be considered in the differential diagnosis of crusted and ulcerated lesions of the lip. Bolognia, Jean L., ed. Relevant allergens related to contact cheilitis: fragrant substances, peruvian balm and nickel. Home; Log in; Dermatology Therapy. Freedberg, Irwin M., ed. A short summary of this paper. Lesions occur almost exclusively on the lower lip, predominantly at the vermillion border, thus reinforcing its direct relationship with the sun. The patient may complain of prurigo, burning sensation and tenderness of affected area and eczema in other parts of the body, depending on the source and manifestation of allergy aiding differential diagnosis. 1987. pp. AC may be painless, but it can lead to Generally, the forms most commonly reported in the literature are angular, contact (allergic and irritant), actinic, glandular, granulomatous, exfoliative and plasma cell cheilitis. diagnosis of glandular cheilitis or actinic cheilitis, a histologically malignant tumour is already present in 18-35 per cent of the cases. 255-64. The condition is also known as solar keratosis.. Actinic keratoses are ultraviolet (UV) light-induced lesions of the skin, which are by far the most common lesions with malignant potential to arise on the skin. vol. Like discrete actinic keratoses, actinic cheilitis is also a premalignant condition related to cumulative lifetime sun exposure. (Aug 1987). Cheilitis can also be a symptom of a contact reaction to an irritant or allergen, or may be provoked by sun exposure (actinic cheilitis) or drug intake, especially retinoids. It is a premalignant condition, as it can develop into squamous cell carcinoma (a type of mouth cancer It is significantly more common in men, elderly patients, and fair-skinned patients. Dermatology, pp.1090-1091. June Robinson. The differential diagnosis of AC includes actinic lichen planus (ALP), herpes simplex lesions, exfoliative cheilitis, contact cheilitis (CC), autoimmune blistering disease including pemphigus vulgaris (PV), lichenoid drug eruptions, cheilitis granulomatosa (CGM), cheilitis grandularis (CGL), and early carcinoma in situ (CIS) [11, 12]. Actinic cheilitis is a diagnosis made from clinical and histopathology evaluation. It is a pre-cancerous condition squamous cell carcinoma of the lip) that most commonly occurs in light-skinned individuals, and in people who live in hot, dry climates and/or work outdoors, like construction workers. cystadenoma, Cutaneous squamous cell carcinoma . Skin biopsy is the golden standard regarding the evaluation of a persistent suspicious lesion on the lip. Fitzpatrick's Dermatology in General Medicine. The clinical appearance and histologic aggressiveness cannot be evaluated clinically (Manganaro et al., 1997) and the clinician must rely on histological examination of the tissues for a correct diagnosis. 37 Full PDFs related to this paper. Differential diagnosis can include chronic lip licking, granulomatous cheilitis, drug-induced cheilitis, contact dermatitis, cheilitis glandularis, lupus erythematosus, and lichen planus. Actinic cheilitis - the same lesion on the lip. Eczematous cheilitis: Reddish scaly eruptions are present in both lips and perioral skin with edema, fissures, vesicles and superficial ulceration [3]. An appropriate history can help elicit the proper diagnosis, such as inquiring about new medications or lip balms, lip-licking habits, and cumulative sun exposure. Differential diagnosis Differential diagnosis may include cheilitis granulomatosa, cutaneous lupus erythematosus (see this term) angioedema, atopic cheilitis, actinic cheilitis, and benign and malignant minor salivary gland tumours (e.g. David Picascia. PMID 3305604. 721-725, 741. 17. David Picascia. J Am Acad Dermatol 17 (2 Pt 1): 255-64. Actinic cheilitis: scaly red roughness with induration, fissuring, and ulceration of the lower lip to the commissures. Lumican as a novel marker for differential diagnosis of Bowen disease and actinic keratosis. The differential diagnosis of exfoliative cheilitis include: • Atopy • Candida yeast infection • Hypervitaminosis A • Actinic cheilitis • Cheilitisglandularis • Contact dermatitis • Photosensitivity. Actinic cheilitis is a lesion of the lip that is analogous to actinic keratosis. Actinic keratosis (AK) lesions are skin-coloured, yellowish, or erythematous, ill-defined, irregularly shaped, small, scaly macules or plaques localised in sun-exposed areas of the body. New York: McGraw-Hill, 2003. Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease. (2009). 2004 Edition | Editors: N. Levine, C. C. Levine. Objective: describe two clinical cases of exfoliative cheilitis, focusing on the differential diagnosis. Search. ... • Lymphoma is a rare differential diagnosis. New York: Mosby, 2003. Journal of the American Academy of Dermatology, 1987. June Robinson. Clinical reviews II I I III II I II I Actinic cheilitis: A i:eview of the etiology, differential diagnosis, and treatment David D. Picascia, M.D., and June K. Robinson, M.D. The pathological features of actinic cheilitis are variable thickening or atrophy of the lip, partial thickness epidermal dysplasia , … J Am Acad Dermatol. Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Clinical Information and Differential Diagnosis of Cheilitis, Actinic References. Chicago, IL With today's increase in sun worshippers, the number of sun-induced skin lesions is increasing. It usually appears as very chapped lips, then may turn white or scaly. It is essential to distinguish between cheilitis (benign inflammation), premalignant actinic cheilitis, and squamous cell carcinoma. or. Actinic cheilitis is a condition where the outer layer of the lips becomes damaged. Actinic cheilitis (AC) is a lip inflammation caused by long-term sunlight exposure. ... non-actinic cheilitis, reported by O’Gorman and Torgerson, the most signifi cant allergens were fra-grance mixes, Myroxilon pereirae resin, dodecyl gallate, octyl gallate, and benzoic acid13. “Actinic cheilitis:a review of the etiology, differential diagnosis, and treatment”. 6 th ed, pp. Cheilitis glandularis: As the patient had swollen lips, nodular growth with an everted margin, ulceration; cheilitis glandularis, a chronic inflammatory condition manifesting as a minor salivary gland hypersecretion with ductal ectasia can be considered. Actinic cheilitis is usually diagnosed clinically. Saunders. Download with Google Download with Facebook. A skin biopsy may be taken if skin cancer or an inflammatory cause of cheilitis is suspected. Skip to main content Skip to table of contents. Actinic Cheilitis . It may coexist with solar lentigo, cutaneous squamous cell carcinoma, and lentigo maligna. Bowen's disease - full thickness involvement ... Robinson, JK. Factitious cheilitis is a chronic condition characterized by crusting and ulceration that is probably secondary to chewing and sucking of the lips. Differential diagnosis: The clinician should consider squamous cell carcinoma as the primary diagnosis. We emphasized the clinical management, diagnosis criteria and treatment, taking into consideration that GC is a rare condition and makes a differential diagnosis with other entities that may occur on lips. Download Full PDF Package . Actinic prurigo • Familial photodermatitis, Seen in High altitude especially in Latin America, and in China. "Actinic cheilitis: a review of the etiology, differential diagnosis, and treatment.". Skin biopsy is the golden standard regarding the evaluation of a persistent suspicious lesion on the lip. Actinic cheilitis is a diagnosis made from clinical and histopathology evaluation. 44. Search SpringerLink. 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